Amyloid protein identification, paraffin, LC-MS-MS

Alphabetical Test listing

Amyloid protein identification, paraffin, LC-MS-MS-Pathology add-on

  
Amyloid protein identification, paraffin, LC-MS-MS
  
Pathology add-on
  
Amyloid AA
Amyloid AL
Amyloid ATTR
Amyloid LECT-2
Amyloid
GPAMYPROPAR
GPMSCBB
  
  • In all cases with adequate tissue, an initial Congo red stain is performed before mass spectrometry testing to confirm positivity and pattern of amyloid deposition can be considered when interpreting mass spectrometry results.
  • In some instances, per pathologist discretion, a different initial Congo red stain may be performed using SS2PC / Special Stain, Group II, Other
    • If the stain is negative for amyloid, then this test will not be performed
    • If the stain is positive for amyloid, this test will be performed
  

This test should only be ordered on patients in whom a primary diagnosis has already been established

  
Tissue
  
  • Testing can only be performed on FFPEtissue blocks.; Do not send fixed tissue slides 
  

Formalin-fixed paraffin-embedded (FFPE) tissue block

  

B5-fixed paraffin-embedded (FFPE) tissue block

  
  • Preliminary pathology report and history are required
  • A brief explanatory note or consultative letter is also recommended
  

Ambient (preferred)

Refrigerated (OK)

  
  • Fixed tissue slides
  • Wet/frozen tissue
  • Cytological smears
  • Nonformalin fixed tissue
  • Non paraffin-embedded tissue
  
Mayo Clinic Laboratories (AMPIP): R-NX
  
Mo - Fr
  
7 - 15 days
  

Histological stain Liquid chromatography-tandem mass spectrometry (LC-MS/MS)

  

An interpretative report will be provided

  
88313
82542 (if appropriate)
88380 (if appropriate)
  
05/21/2018
  
11/14/2018