ETV6/RUNX1 or TEL/AML or t(12;21), or amplification of RUNX1 (iAMP21) rearrangements are recurring abnormalities in B-cell ALL. According to current NCCN B-ALL guidelines, ETV6/RUNX1 or TEL/AML or t(12;21) abnormalities are classified as a good cytogenetic risk factor, and amplification of RUNX1 (iAMP21) is classified as a poor cytogenetic risk factor.
This test can be ordered individually or as part of the B-ALL FISH Panel. See the panel test for more details.
Bone marrow aspirate:
Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube
- or -
Transfer aspirate from syringe to transport container.
Submit entire specimen unspun.
Bone Marrow Core:
Submit in sterile tube/cup filled with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline
Dk green Sodium heparin (Na hep), no gel
Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times to prevent clotting.
Submit entire specimen unspun
AHL Cytogenetics Oncology Request
Fluorescence in situ hybridization (FISH)
Normal or Abnormal with interpretation