Beta amyloid by IHC

Alphabetical Test listing

Beta amyloid by IHC-12376 - Technical only, 12379 - Technical & interpretation

Beta amyloid by IHC
12376 - Technical only, 12379 - Technical & interpretation
  • All IHC stains will include a positive control tissue
  • Beta amyloid is used to identify amyloid angiopathy, and is more sensitive than congo red stains
  • This antibody can also identify Alzheimer's neurofibrillary tangles
  • This antibody will not identify the other types of amyloid (use kappa and lambda to identify primary amyloidosis/plasma cell dyscrasias; we don't have antibodies to the SAA (serum amyloid associated protein) or beta 2 microglobulin protein types of amyloid

Prepare a formalin-fixed, paraffin-embedded (FFPE) tissue block


FFPE tissue block


Tissue section mounted on a charged, unstained slide


Ambient (preferred)

  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
AHL - Immunohistochemistry
Mo - Fr
1 - 2 days

Immunohistochemical staining and microscopic examination


If requested, an interpretive report will be provided



  • Beta amyloid is an extracellular filamentous protein deposit found in the brain, and is the major protein of amyloid cores, neuritic plaques, and neurofibrillary tangles
  • This protein is found in Alzheimer's disease, and other rare types of dementia
  • Beta amyloid is also found in amyloid angiopathy, which is a leading cause of spontaneous intracerebral hemorrhage in the elderly

Staining patterns

  • Cytoplasmic staining


  1. Ishihara T et al: The significance of cerebrovascular amyloid in the aetiology of superficial (lobar) cerebral hemorrhage and its incidence in the elderly population. J Pathol 1991; 165:229-234.
  2. Vinters HV et al: Immunohistochemical study of cerebral amyloid angiopathy. III: Widespread Alzheimer A4 peptide in cerebral micro-vessel walls co-localizes with gamma trace in patients with leukoencephalopathy. Ann Neurol 1990; 28: 34-42.
88342 - 1st stain
88341 - each additional stain