Melan A by IHC

Alphabetical Test listing

Melan A by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
Melan A by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
A103
  
  • All IHC stains will include a positive control tissue
  
  • Expresses virtually all nevi with an exception of neurotized melanocytes with prominent Schwannian differentiation
  • Stains all melanomas with epithelioid or mixed spindle and epithelioid type
  • Is more sensitive than HMB45 in identifying desmoplastic melanoma and less sensitive than S100 (Melan-A may stain <50% of cells in desmoplastic melanomas)
  • Can detect a small number of HMB45 negative metastatic melanomas and a rare case of S100 negative metastatic melanoma. In one study of 75 metastatic melanomas, 81% were reactive with Melan-A and 75% with HMB45. 85% of cases stained for one or both antibodies
  • Proved to be a useful adjuvant to the HMB45/S100/Cytokeratin panel for the diagnosis of malignant melanomas in the cytological effusions
  • Melan-A also has been reported to stain steroid producing cells of the ovary, testes and adrenal cortex
  
Tissue
  

Submit a formalin-fixed, paraffin embedded tissue

  

Formalin-fixed, paraffin embedded (FFPE) tissue block

  

FFPE tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • Is a transmembrane protein composed of 118 amino acids

Staining pattern

  • Cytoplasmic granular staining. The staining pattern strong in epithelioid melanocytes

  
88342 - 1st stain
88341 - each additional stain
  
07/17/2017
  
10/19/2018
  
10/02/2020