Melan A by IHC

Alphabetical Test listing

Melan A by IHC-12376 - Technical only, 12379 - Technical & interpretation

Melan A by IHC
12376 - Technical only, 12379 - Technical & interpretation
  • All IHC stains will include a positive control tissue
  • Expresses virtually all nevi with an exception of neurotized melanocytes with prominent Schwannian differentiation
  • Stains all melanomas with epithelioid or mixed spindle and epithelioid type
  • Is more sensitive than HMB45 in identifying desmoplastic melanoma and less sensitive than S100 (Melan-A may stain <50% of cells in desmoplastic melanomas)
  • Can detect a small number of HMB45 negative metastatic melanomas and a rare case of S100 negative metastatic melanoma. In one study of 75 metastatic melanomas, 81% were reactive with Melan-A and 75% with HMB45. 85% of cases stained for one or both antibodies
  • Proved to be a useful adjuvant to the HMB45/S100/Cytokeratin panel for the diagnosis of malignant melanomas in the cytological effusions
  • Melan-A also has been reported to stain steroid producing cells of the ovary, testes and adrenal cortex

Submit a formalin-fixed, paraffin embedded tissue


Formalin-fixed, paraffin embedded (FFPE) tissue block


FFPE tissue section mounted on a charged, unstained slide


Ambient (preferred)

  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
AHL - Immunohistochemistry
Mo - Fr
1 - 2 days

Immunohistochemical staining and microscopic examination


If requested, an interpretive report will be provided



  • Is a transmembrane protein composed of 118 amino acids

Staining pattern

  • Cytoplasmic granular staining. The staining pattern strong in epithelioid melanocytes

88342 - 1st stain
88341 - each additional stain