The euglobulin lysis time is a global nonspecific screen of the fibrinolytic system.
Frozen (srict) – 12 months
Refrigerated – NO
Ambient – NO
In the ELT test, plasma inhibitors of fibrinolysis are physically removed and the reaction of fibrinogen, plasminogen, and plasminogen activators are assayed. The precipitate also includes tissue plasminogen activators, plasminogen, plasmin, and fibrinogen. The inhibitors of lysis, α2-antiplasmin, and α2-macroglobulin, do not precipitate. In the test system, the euglobulin precipitate is redissolved in buffer, and clotting is initiated with calcium. The assay is performed in a microtiter plate. The time required for the intrinsic plasmin to lyse the fibrin clot equates to the euglobulin lysis time.
Abnormal (see result interpretation)
This is a semiquantitative assay. The diagnostic potential of euglobulin lysis times is limited by the extreme variation in lysis times among healthy individuals.6 Both hypofibrinogenemia and factor XIII deficiency may result in a shortened lysis time. In the case of hypofibrinogenemia, the shortened time is due to the decreased amount of fibrin to be lysed. In factor XIII deficiency, the clot is not stabilized by covalent cross-linking of fibers and can be readily lysed by plasmin.