Pemphigus/Pemphigoid profile I

Alphabetical Test listing

Pemphigus/Pemphigoid profile I-994

  
Pemphigus/Pemphigoid profile I
  
994
  
LAB994
  
MSO
  
Cutaneous Immunofluorescence
  

The detection of anti-skin (IC and BMZ) antibodies aids in the diagnosis, and sometimes prognosis, of chronic vesicular-bullous diseases including pemphigus, pemphigoid, cicatricial pemphigoid, and epidermolysis bullosa acquisita (EBA).

  
Serum
  
  
1.0 mL
  
0.5 mL
  

Spin, separate and freeze

  
  

Frozen (preferred) - 1 year

Refrigerated - 5 days

Ambient - 48 hours

 

  
  • Grossly hemolysis
  • Lipemia
  • Icteric specimens
  
IMMCO Diagnostics Inc (122) via LabCorp (806399): R-NX
  
Mo - Fr
  
3 - 5 days
  

Semi-quantitative Indirect Immunofluorescence (IFA)

Substrate: Rhesus Monkey and Guinea Pig Esophagus/NaCl Split-Skin Substrate

  

An interpretive report will be provided

  

Epithelial intercellular antibodies are diagnostic for pemphigus and occur in over 90% of patients with active forms. Because of the species specificity of intercellular antibodies, the use of the dual substrates further distinguishes the intercellular antibodies of pemphigus vulgaris and vegetans from the antibodies of pemphigus foliaceus and erythematosus. Antibodies to basement membrane antigens of stratified squamous epithelium occur in about 70% of active bullous pemphigoid, 50% of vesicular pemphigoid and EBA and 10% of cicatricial pemphigoid patients.

  
86256 x 2
  
05/24/2019
  
12/26/2019
  
05/20/2020