B-ALL panel by FISH

Alphabetical Test listing

B-ALL panel by FISH-Order individual components: 4280H (blood) or 4280G (bone marrow)

  
B-ALL panel by FISH
  
Order individual components: 4280H (blood) or 4280G (bone marrow)
  
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES
LAB4280G - CYTOGENETIC BONE MARROW STUDIES
  
BCR/ABL1
MLL
4/10
ETV/RUNX1
  
B-ALL
B-cell ALL
iAMP21he
FISH
Fluorescence in situ hybridization
Mixed Lineage Leukemia
Trisomy 4
Trisomy 10
TEL/AML
t(12;21)
t(11q23;?)
  

The B-ALL FISH Panel is useful for detecting the prognostically significant cytogenetics FISH abnormalities used in the both the pediatric and adult B-Cell ALL according to the NCCN guidelines.

  
Sodium heparin (Na hep) whole blood
  
  
5 mL
  
2.0 mL
  

Dk green Sodium heparin (Na hep), no gel

  
Bone marrow
EDTA whole blood (a chromosome analysis study is not recommended for this specimen type)
  

EDTA whold blood:

Lavender (EDTA), 4mL

  
Bone marrow: 10 mL (minimum 5 mL)
  

Bone marrow

Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube

  

- or -

Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel

  

EDTA whole blood:

Lavender (EDTA), 4mL

Bone marrow:

Sterile vial/tube

Dk green Sodium heparin (Na hep), no gel

 

  
  • AHL Cytogenetics oncology request
  

Ambient

  
Pellets - 2 years
  
  • Improper label (unlabeled or mislabeled)
  • Wrong container (anticoagulant or solution)
  • Improper blood/anticoagulant ratio
  • Delay in transport
  • Improper storage
  • Leaking container
  
AHL - Cytogenetics: X
  
2 - 3 times per week
  
5 - 7 days
  

Fluorescence in situ hybridization (FISH)

  

Normal or Abnormal with interpretation.

Aneuploidy of chromosomes 4 and 10 and t(12;21) ETV6/RUNX1 rearrangements are classified as favorable cytogenetics prognostic indicators in B-ALL.

BCR/ABL1 and MLL rearrangements and intrachromosomal amplification of chromosome 21 (iAMP21) are unfavorable cytogenetics prognostic indicators in B-ALL.

  
88271 x 8
88275 x 4
  
Yes
  
  
03/23/2021