PLAP by IHC

Alphabetical Test listing

PLAP by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
PLAP by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
Placental alkaline phosphatase
  
  • All IHC stains will include a positive control tissue
  
  • Useful as a general screening marker for germ cell tumors and is positive in most
  • Classic seminomas/dysgerminomas are almost all PLAP positive
  • Spermatocytic seminomas are usually negative for PLAP
  • Embryonal carcinomas are usually (95%) positive for PLAP
  • Teratomas may or may not stain positively for PLAP
  • Endodermal sinus tumors are usually positive for PLAP
  • Choriocarcinomas typically are positive for PLAP
  • Intratubular germ cell neoplasia usually stains positively for PLAP
  • Various somatic carcinomas, including those of breast, lung, GI tract, ovary, prostate and bladder origin, have been reported to be positive for PLAP on occasion
  • PLAP positivity has also been reported in partial and complete hydatiform moles

Note: There is cross-reactivity of this antibody with intestinal alkaline phosphatase.
Staining of striated muscle with PLAP has been observed and reported.

  
Tissue
  

Submit a formalin-fixed, paraffin embedded tissue block

  

Formalin-fixed, paraffin embedded (FFPE) tissue block

  

FFPE tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • Anti-placental alkaline phosphatase labels trophoblasts in placental tissue

Staining pattern

  • Cytoplasmic and apical based staining

References

  1. Ulbright TM: Germ Cell Neoplasms of the Testis; American Journal of Surgical Pathology; 17(11):1075-1091, 1993.
  
88342 - 1st stain
88341 - each additional stain
  
08/07/2017
  
10/19/2018
  
10/02/2020