Detection of hereditary decreases in the production of α1-antitrypsin (α1AT). Decreased or nearly absent levels of α1AT can be a factor in chronic obstructive lung disease and liver disease. An increased prevalence of non-MM phenotypes is found with cryptogenic cirrhosis and with CAH. Cirrhosis in a child should raise consideration of α1AT deficiency or Wilson's disease. Diagnosis of inflammatory states, if elevated (eg, rheumatoid arthritis, bacterial infection, vasculitis, neoplasia).
Overnight fasting prior to sample collection is preferred
Immediatley following collection, mix sample by gently inverting 5 times
Spin
Gold serum separator (SST) tube
Red/lavender - spin and separate
Lt Green PST - spin
Ambient (preferred) |
14 days |
Refrigerated |
14 days |
Frozen |
14 days |
Freeze/thaw cycles |
Stable x3 |
Immunologic
See report