Cytokeratin cocktail by IHC

Alphabetical Test listing

Cytokeratin cocktail by IHC-12376 - Technical only, 12379 - Technical & interpretation

Cytokeratin cocktail by IHC
12376 - Technical only, 12379 - Technical & interpretation
CK cocktail

All IHC stains will include a positive control tissue


Submit a formalin-fixed, paraffin-embedded tissue


Formalin-fixed, paraffin-embedded (FFPE) tissue block


FFPE tissue section mounted on a charged, unstained slide


Ambient (preferred)

  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
AHL - Immunohistochemistry
Mo - Fr
1 - 2 days

Immunohistochemical staining and microscopic examination


If requested, an interpretive report will be provided



  • Family of 20 different heterogenous proteins 40-70 kD NW
  • All epithelial cells contain cytokeratins, but different types of epithelium contain different keratin profiles
  • Low MW found in simple and glandular epithelium; High MW found in complex stratified epithelium
  • CK cocktails cover the widest range of kD weights

Staining pattern

Cytoplasmic Anomalous CK expression:

  • melanomas
  • smooth muscle cells and smooth muscle tumors
  • astrocytes and astro. tumors (glioblastoma multiforme)
  • endothelial cells and angiosarcomas

When a routine CK is ordered, a cocktail of 3 different cytokeratins is automatically used: AE1-AE, CAM5.2 and CK18.


  1. Moll et. al.; The Catalog of Human Cytokeratins: Patterns of Expression in Normal Epithelia, Tumors and Cultured Cells; Cell 31:11-24, 1982.
88342 - 1st stain
88341 - each additional stain