BG-8 by IHC

Alphabetical Test listing

BG-8 by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
BG-8 by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
Blood group 8
  
  • All IHC stains will include a positive control tissue
  
  • Useful in identifying cells of epithelial origin
  • Reacts with 92-100% of lung adenocarcinomas (strong, diffuse cytoplasmic staining)
  • Mesotheliomas (8-23%) will also stain, but the reactivity is weak and usually limited to a few cells
  • Patients with Lewis Y antigen on their blood cells will also show positive staining in the RBC's
  
Tissue
  

Submit a formalin-fixed, paraffin embedded tissue block

  

Formalin-fixed, paraffin embedded (FFPE) tissue block

  

Tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • BG-8 is a monoclonal antibody raised against a lung cancer cell line that also recognizes the blood group antigen Lewis Y

Staining patterns

  • Cytoplasmic staining

References

  1. Ordonez NG. The immunohistochemical diagnosis of epithelial mesothelioma. Hum Pathol 1999; 30: 313-23.
  2. Riera JR, et al: The immunohistochemical diagnostic panel for epithelial mesothelioma. A reevaluation after heat-induced epitope retrieval. Am J Surg Pathol 21:1409-1419, 1997.
  3. Jordon D. et al: Blood group antigens Lewis X and Lewis Y, in the diagnostic discrimination of malignant mesothelioma versus adenocarcinoma. Am J Pathol 135:931-937, 1989.

 

  
88342 - 1st stain
88341 - each additional stain
  
05/15/2017
  
10/17/2018
  
10/02/2020