Anti-Hu, Ri, Yo antibody profile, serum

Alphabetical Test listing

Anti-Hu, Ri, Yo antibody profile, serum-994

Test name:

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Useful for:

Evaluation of patients with suspected paraneoplastic neurologic syndrome such as encephalomyelitis

Specimen type:

Serum

Collection container:

Red serum vial/tube, 5 mL

Volume:

2.0 mL

Minimum volume:

1.0 mL

Processing instructions:

Allow specimen to clot
Spin within two (2) hours of sample collection
Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum

Transport container:

Transfer vial/tube with cap - 12mL (LabCorp)

Transport and stability:

Ambient (preferred) - 14 days

Refrigerated - 14 days

Frozen - 14 days

Freeze/thaw cycles - stable x 3

Specimen retention time:

1 week

Reason for rejection:

Gross hemolysis
Gross lipemia

Performing lab:

LabCorp Burlington (505240): R-NX

Days set up:

We (or as needed)

TAT:

5 days

Method:

Immunofluorescence (IFA)

Reference ranges:

Negative

Clinical information:

Antibodies to Hu, Ri and Yo antigens are present in patients with paraneoplastic neurologic syndrome such as encephalomyelitis. Hu antibodies are frequently associated with small cell lung cancer and neuroblastoma. Hu antibodies are rarely associated with non-small cell lung cancer, prostate cancer or seminoma. the paraneoplastic syndrome associated with the presence of antibodies to Ri includes symptoms such as opsocionus, ataxia, nystagmus, dizziness and dysarthria. Antibodies to Yo are associated with cerebellar degeneration as well as with small lung cancer, gynecologic and breast cancer.

CPT codes:

86255 x 3

Date created:

01/29/2021

Review date:

12/31/2023