Mammaglobin by IHC

Alphabetical Test listing

Mammaglobin by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
Mammaglobin by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
MGB1
  
  • All IHC stains will include a positive control tissue
  
  • Mammaglobin staining has been reported in 48 -80% of breast cancers
  • Uterine adenocarcinomas (3/23, 13%), salivary gland tumors (6/11, 55%), and sweat gland carcinomas (4/10; 40%) have been reported to stain for this marker
  • Other tumors reported to have stained for this marker include melanoma, ovarian tumors, and pancreatic adenocarcinoma (1 case)
  • Mammaglobin expression may be helpful in discriminating lung from breast tumors, since no lung tumors have been found to stain for this marker (0/106; 1, and 0/40; 3)
  • Mammaglobin is more sensitive than GCDFP-15 (AP-15), but is less specific 3
  
Tissue
  

Submit a formalin-fixed, paraffin embedded tissue

  

Formalin-fixed, paraffin embedded (FFPE) tissue block

  

FFPE tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • Mammaglobin is a protein that is found in neoplastic breast cells, a subset of normal breast epithelial cells

Staining pattern

  • Cytoplasmic

References

  1. Sasaki E et al: Breast-specific expression of MGB1/mammaglobin; an examination of 480 tumors from various organs and clinicopathological analysis of MGB1-positive breast cancers. Mod Pathol, 2007, Feb; 20(2): 208-14.
  2. Fleming TP et al: Mammaglobin, a breast-specific gene, and its utility as a marker for breast cancer. Ann N Y acad Sci. 2000; 923:78-89.
  3. Bharbava R et al: Mammaglobin vs GCDFP-15; an immunohistologic validation survey for sensitivity and specificity. Am J Clin Pathol 2007; 127:103-113.
  
88342 - 1st stain
88341 - each additional stain
  
07/17/2017
  
10/19/2018
  
10/02/2020