High in sarcoidosis, more often when the disease is active. Of value in assessing the response of sarcoidosis to corticosteroid therapy.
Stop administration of Captopril, Enalapril, or Lisinopril for 12 hours prior to sample collection (reduces ACE activity).
Immediatley following collection, mix sample by inverting 5 times
Gold serum separator (SST) tube
Ambient (preferred) - 7 days
Refrigerated - 7 days
Frozen - 3 days
Freeze/thaw cycles - stable x3
0 - 2 years: 18 - 95 units/L
3 - 14 years: 22 - 108 units/L
≥ 15 years: 14 - 82 units/L
Changes in serum ACE correlate with clinical status and results of gallium scans (which reflect presence and activity of inflammatory granulomatous lesions). Falling ACE level is a favorable prognostic sign. Rising levels may reflect activity uncontrolled by therapy.