Amyloid A by IHC

Alphabetical Test listing

Amyloid A by IHC-12376 - Technical only, 12379 - Technical & interpretation

Amyloid A by IHC
12376 - Technical only, 12379 - Technical & interpretation
Serum Amyloid A
  • All IHC stains will include a positive control tissue
  • Most inflammatory HAs show strong SAA staining, which can be patchy or diffuse (>90%)
  • SAA is negative in most (83%) of FNH cases (rare cases show patchy or diffuse staining)

Submit a formalin-fixed, paraffin embedded tissue block


Formalin-fixed, paraffin embedded (FFPE) tissue block


Tissue section mounted on a charged, unstained slide


Ambient (preferred)

  • Unlabeled/mislabeled
  • Insufficient tissue
  • Slides broken beyond repair
AHL - Immunohistochemistry
Mo - Fr
1 - 2 days

Immunohistochemical staining and microscopic examination


If requested, an interpretive report will be provided



  • This antibody labels amyloid A (AA) in tissues and can be used to classify AA-amyloidosis.
  • This antibody does not react with other amyloid types, such as Alzheimer’s amyloid plaques
  • SAA can be used in a panel with glutamine synthetase and beta catenin to help differentiate between hepatic adenomas (HA) and focal nodular hyperplasia (FNH)

Staining patterns

  • Strong cytoplasmic staining



  1. Linke RP: Monoclonal antibodies against amyloid fibril protein AA. Production, specificity and use for immunohistochemical localization and classification of AA-type amyloidosis. J Histochem Cytochem 1984;32:322-8.
  2. Shafizadeh N et al: Diagnosis of well-differentiated hepatocellular lesions: role of immunohistochemistry and other ancillary techniques. Adv Anat Pathol 2011;18:438-445).
  3. Joseph NM et al: Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma. Modern Pathology (2014) 27, 62–72; doi:10.1038/modpathol.2013.114.
88342 - 1st stain
88341 - each additional stain