Clorazepate, serum or plasma

Alphabetical Test listing

Clorazepate, serum or plasma-994

  
Clorazepate, serum or plasma
  
994
  
LAB994
  
MSO
  
Tranxene
SD
Tranxene
T-Tab
  
  • Evaluate toxicity
  • Monitor therapeutic levels
  

The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel.

Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.

  
Serum
  
  
1.0 mL
  
0.4 mL
  

Unless otherwise directed, specimen should be collected just prior to next dose

  

Spin and separate

  
Heparin plasma
EDTA plasma
  

Dk green heparin (Li or Na), no gel

 

Lavender (EDTA), 4mL

  

Refrigerated (preferred) - 14 days

Ambient - 1 day

Frozen - 14 days

  
  • Gel-barrier tubes
  
LabCorp Burlington (007930): R-NX
  
Tu - Fr
  
3 - 6 days
  

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

  

Therapeutic: 0.5 - 2.0 µg/mL (reported as Nordiazepam)

 

  

Potentially toxic: >5.0 µg/mL (reported as Nordiazepam)

  
The drug is used in the treatment of general anxiety disorder, the management of ethanol withdrawal, and as an adjunct anticonvulsant drug.
  • Half-life of elimination: 40 to 50 hours.
  • Time to peak serum: approximately one hour.
  
80346
  
Yes
  
  
05/21/2019
  
05/29/2019