Porphyrins, quantitative, random urine

Alphabetical Test listing

Porphyrins, quantitative, random urine-13518

Porphyrins, quantitative, random urine
  • Coproporphyrin (CP) I
  • Coproporphyrin (CP) III
  • Heptacarboxylporphyrins (7-CP)
  • Hexacarboxylporphyrins (6-CP)
  • Pentacarboxylporphyrins (5-CP)
  • Uroporphyrins (UP) 

Urine porphyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Evaluation of neurologic and/or psychiatric symptoms associated with acute porphyrias, such as acute intermittent porphyria (AIP), requires urine porphobilinogen (PBG) testing.

For initial evaluation of porphyrias. Use Porphyrins, Quantitative, 24-hour urine [13486] to follow upabnormal random urine results.

Urine, random
2.0 mL
1.5 mL
  1. Transfer 2mL of to a Amber screw-cap polypropylene frozen transport tube/vial - 4mL (LabCorp)
  2. Freeze

Protect from light

Frozen (preferred) - 14 days

Freeze/thaw cycles - stable x3

Refrigerated - 7 days

Ambient - NO


  • Stored specimen not refrigerated
  • Specimen exposed to light
  • Acid preservative
  • pH <3
LabCorp Burlington (120980): R-LC
Mo - Fr
3 - 5 days

High-pressure liquid chromatography (HPLC) with fluorometric detection



Coproporphyrin (CP) I:   0−15 μg/L
Coproporphyrin (CP) III:   0−49 μg/L
Heptacarboxylporphyrins (7-CP): 0−2 μg/L
Hexacarboxylporphyrins (6-CP): 0−1 μg/L
Pentacarboxylporphyrins (5-CP): 0−2 μg/L
Uroporphyrins (UP):    0−20 μg/L

Excess urinary porphyrin excretion, or porphyrinuria, results from inhibition of key enzymatic steps in such clinical conditions as genetic deficiencies in heme production enzymes, hepatitis, renal disease, and erythroid disease, as well as by heavy metal inhibition of heme enzyme synthesis. Both in experimental animals and in humans exposed to heavy metals, elevated levels of porphyrins have been found in urine.

Result 11228-4