Thyrotropin receptor antibody, serum

Alphabetical Test listing

Thyrotropin receptor antibody, serum-13346

Thyrotropin receptor antibody, serum
Long-acting thyroid stimulator
Thyrotropin-binding inhibitory immunoglobulin
TSH Receptor Ab
TSH receptor binding inhibitory immunoglob

Diagnosis of hyperthyroidism and Graves' disease.

Thyrotropin-receptor antibody is an autoantibody to the thyroid cell receptor for thyroid-stimulating hormone. It can be demonstrated in 90% of patients with Graves' disease, and is the cause of the hyperthyroidism of that condition. The characterization of TRA resolved much confusion about long-acting thyroid stimulator (LATS) and LATS protector, which are both, in fact, thyroid-stimulating autoantibodies which simply behaved differently in animal test systems. These antibodies are present in 50% of euthyroid Graves' disease as well as hyperthyroid patients. They play a major role in the pathogenesis of Graves' disease. Detection of these antibodies is useful in prediction of neonatalhyperthyroidism and prediction of relapse of hyperthyroidism.


This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R).

It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

1.0 mL
0.7 mL
Note: This volume does not allow for repeat testing



Gold serum separator (SST) tube


Spin and separate


Refrigerated (preferred) - 3 days
Frozen - 1 month
   Freeze/thaw cycles: x1


  • Citrate plasma specimen
  • Samples collected in heparin or from patients on heparin therapy
  • Lipemic samples
  • Hemolyzed samples
  • Improper labeling
LabCorp Burlington (010314): R-LC
1 - 2 days

Electrochemiluminescence Immunoassay (ECLIA)


0.0 - 1.75 units/L

Biotin interference - see Patient preparation
Result 5385-0