CD20 by IHC

Alphabetical Test listing

CD20 by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
CD20 by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
L26
  

All IHC stains will include a positive control tissue

  
  • CD20 is a very useful antibody which can identify most B cell lymphomas (approximately 95%)
  • CD20 also identifies Reed-Sternberg variants of nodular lymphocyte predominance Hodgkin’s disease (see section on immunohistochemistry panels)
  • Rare examples of CD20 positive T cell NHL have been reported3
  
Tissue
  

Submit a formalin-fixed, paraffin-embedded tissue

  

Formalin-fixed, paraffin-embedded (FFPE) tissue block

  

FFPE tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications:

  • CD20 Reacts with an antibody found on the majority of B cells and is virtually B-cell specific

 
Staining pattern:

  • Cell surface membrane based and/or cytoplasmic pattern

References

  1. Cartun et. al.: Utilization of Monoclonal Antibody L26 in the Identification and Confirmation of B Cell Lymphomas. A Sensitive and Specific Marker Applicable to Formalin and B5 Fixed, Paraffin-embedded Tissues; American Journal of Clinical Pathology 129:415-421, 1987.
  2. Mason et. al.: Antibody L26 Recognizes and Intracellular Epitope on the B Cell Associated CD20 Antigen; American Journal of Clinical Pathology 135:1215-1222, 1990.
  3. Martinez et. al.: CD20 + T Cell Lymphoma; American Journal of Clinical Pathology 102:483-489, 1994.
  
88342 - 1st stain
88341 - each additional stain
  
06/16/2017
  
10/17/2018
  
10/02/2020