Aneuploidy 4/10 by FISH
Aneuploidy 4/10 by FISH-4280G (bone marrow) or 4280H (blood)
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES
B-Lymphoblastic Leukemia/lymphoma
B-ALL
B-cell ALL
FISH
Fluorescence in situ hybridization
Trisomy 4
Trisomy 10
Aneuploidy of chromosomes 4 and 10, is a recurring abnormality in B-cell ALL and an indication of hyperdiploidy. According to current NCCN B-ALL guidelines, gain of chromosomes 4 and 10 are classified as a favorable cytogenetic risk factor.
This test can be ordered individually or as part of the B-ALL FISH Panel. See the panel test for more details.
Bone marrow aspirate:
Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube
- or -
- Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel
- Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times, to prevent clotting
Transfer aspirate from syringe to transport container.
Submit entire specimen unspun.
Whole blood
Touch Prep Slides
Bone Marrow Core:
Submit in sterile tube/cup filled with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline
or
Whole blood:
Dk green Sodium heparin (Na hep), no gel
Whole blood: 5 mL
Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times to prevent clotting.
Submit entire specimen unspun
AHL Cytogenetics Oncology Request
Ambient
- Improper label (unlabeled or mislabeled)
- Wrong container (anticoagulant or solution)
- Delay in transport
- Improper storage
- Leaking container
- Slides broken beyond repair
Fluorescence in situ hybridization (FISH)
Normal or Abnormal with interpretation.