Detecting aneuploidy of chromosomes 4 and 10, recurring abnormalities in B-cell ALL and an indication of hyperdiploidy.
This test can be ordered individually or as part of the B-ALL FISH Panel. See the panel test for more details.
Dk green Sodium heparin (Na hep), no gel
Bone marrow
Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube
- or -
Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel
EDTA whole blood:
Lavender (EDTA), 4mL
Bone marrow:
Sterile vial/tube
Dk green Sodium heparin (Na hep), no gel
Ambient
Fluorescence in situ hybridization (FISH)
Normal or Abnormal with interpretation.
Gain (trisomy) of chromosomes 4 and 10 in combination is an indication of hyperdiploidy. Gain of chromosomes 4 and 10 is considered a favorable cytogenetics risk category in both pediatric and adult B-cell ALL according to NCCN guidelines.