Aneuploidy 4/10 by FISH

Alphabetical Test listing

Aneuploidy 4/10 by FISH-4280H (blood) or 4280G (bone marrow)

  
Aneuploidy 4/10 by FISH
  
4280H (blood) or 4280G (bone marrow)
  
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES
LAB4280G - CYTOGENETIC BONE MARROW STUDIES
  
4/10
  
B-ALL
B-cell ALL
FISH
Fluorescence in situ hybridization
Trisomy 4
Trisomy 10
  

Detecting aneuploidy of chromosomes 4 and 10, recurring abnormalities in B-cell ALL and an indication of hyperdiploidy.

This test can be ordered individually or as part of the B-ALL FISH Panel. See the panel test for more details.

  
Sodium heparin (Na hep) whole blood
  
  
5 mL
  
2.0 mL
  

Only one specimen tube is required to perform all ordered cytogenetics testing.

The more testing requested, the closer to the optimal volume requirements is required.

  

Dk green Sodium heparin (Na hep), no gel

  
Bone marrow
EDTA whole blood (a chromosome analysis study is not recommended for this specimen type)
  

EDTA whole blood: (not recommended)

Lavender (EDTA), 4mL

  
Bone marrow: 10 mL (minimum 5 mL)
  

Bone marrow

Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube

  

- or -

Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel

  

EDTA whole blood:

Lavender (EDTA), 4mL

Bone marrow:

Sterile vial/tube

Dk green Sodium heparin (Na hep), no gel

 

  
  • AHL Cytogenetics oncology request
  

Ambient

  
Pellets - 2 years
  
  • Improper label (unlabeled or mislabeled)
  • Wrong container (anticoagulant or solution)
  • Improper blood/anticoagulant ratio
  • Delay in transport
  • Improper storage
  • Leaking container
  
AHL - Cytogenetics: X
  
2 - 3 times per week
  
5 - 7 days
  

Fluorescence in situ hybridization (FISH)

  

Normal or Abnormal with interpretation.

Gain (trisomy) of chromosomes 4 and 10 in combination is an indication of hyperdiploidy. Gain of chromosomes 4 and 10 is considered a favorable cytogenetics risk category in both pediatric and adult B-cell ALL according to NCCN guidelines.

  
88271 x 2
88275
  
Yes
  
  
03/23/2021