Anti-RNA polymerase III

Alphabetical Test listing

Anti-RNA polymerase III-13643

  
Anti-RNA polymerase III
  
13643
  
LAB13643
  
RNAPOLYMIGG
  
Anti-RNA polymerase 3 Ab
Anti-RNAP III
RNA polymerase III
  

Autoantibodies to RNA Polymerase III antigen are found in 11% to 23% of patients with systemic sclerosis. Patients who are positive for RNA Polymerase III antibodies do not have any of the other antibodies typically found in systemic sclerosis patients such as centromere, Scl-70, or Pm/Scl antibodies. Thus, they are a separate serologic group. Numerous studies have shown that these patients have an increased risk of the diffuse cutaneous form of scleroderma, with high likelihood of skin involvement and hypertensive renal disease. Antibodies to several different types of RNA Polymerases are found in patients with systemic sclerosis. The recombinant immunodominant epitope of RNA Polymerase III can be used in ELISA with high specificity to detect RNA Polymerase III antibodies in patients with the diffuse cutaneous form of systemic sclerosis

  
Serum
  
  
1.0 mL
  
0.3 mL
Note: This volume does not allow for repeat testing
  
  1. Spin and
  2. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp) within one (1) hour of collection
  
  

Refrigerated (preferred) - 14 days

Ambient - 7 days

Frozen - 60 days

 

  
  • Grossly hemolyzed
  • Bacterial contamination
  • Lipemic
  • Icteric
  • Non-serum specimen types
  
LabCorp (520021): R-LC
  
Every 5 days
  
7 - 14 days
  

Enzyme immunoassay (EIA)

  
Negative <20 Units
Weak positive 20 - 39 Units
Moderate positive 40 - 80 Units
Strong positive >80 Units
  
86235
  
04/30/2019
  
08/07/2020
  
08/17/2020