SSTR2a by IHC

Alphabetical Test listing

SSTR2a by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
SSTR2a by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
Somatostatin receptor 2a
  
  • All IHC stains will include a positive control tissue
  
  • SSTR2a is a highly sensitive and specific marker for meningiomas. However, rare meningiomas may show no staining for this marker, and these tumors might be further studied with progesterone receptor and EMA
  • This marker can be used to differentiate spindle cell neoplasms of the central nervous system, in conjunction with S100 (positive in Schwannoma), SOX10 (positive in schwannoma), STAT6 (positive in hemangiopericytoma/solitary fibrous tumor; HPC/SFT), progesterone receptors (positive in meningiomas and some carcinomas), and CD34 (variably positive in HPC/SFT)
  • Positive staining is also seen in pancreatic islets, gastric endocrine cells, and vessels
  
Tissue
  

Submit a formalin-fixed, paraffin embedded tissue block

  

Formalin-fixed, paraffin embedded (FFPE) tissue block

  

FFPE tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • SSTR2a is encoded by the SSTR2 gene and is a transmembrane protein present in cerebrum and kidney.
  • This marker is highly expressed by meningiomas

Staining pattern

  • Strong diffuse membranous and cytoplasmic staining

References

  1. Menke JR, Raleigh DR, Gown AM, Thomas S, Perry A, Tihan T. Somatostatin receptor 2a is a more sensitive diagnostic marker of meningioma than epithelial membrane antigen. Acta Neuropathol. 2015:21.
  
88342 - 1st stain
88341 - each additional stain
  
09/07/2017
  
10/17/2018
  
10/02/2020