Evaluate patients suspected of having polymyositis, dermatomyositis, or polymyositis-scleroderma overlap syndrome.
Anti-Jo-1 antibodies are present in approximately 20% to 30% of patients with adult-onset polymyositis syndromes. They are present in >65% of patients with both myositis and interstitial lung disease. In such patients, the presence of anti-Jo-1 antibodies may be predictive of a response to steroid treatment. Testing for ANAs is not adequate for the detection of anti-Jo-1 antibodies.
Immediatley following collection, mix sample by gently inverting 5 times
Gold serum separator (SST) tube
Ambient (preferred) - 14 days
Refrigerated - 14 days
Frozen - 14 days
Freeze/thaw cycles - stable x 3
Multiplex flow immunoassay
0.0 - 0.9 AI