Human epididymis protein 4

Alphabetical Test listing

Human epididymis protein 4-994

Human epididymis protein 4

The assay is used as an aid in monitoring recurrence or progressive disease in patients with epithelial ovarian cancer. Serial testing for patient HE4 assay values should be used in conjunction with other clinical findings used for monitoring ovarian cancer. Values obtained with different assay methods should not be used interchangeably in serial testing. It is recommended that only one assay method be used consistently to monitor each patient's course of therapy.


This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R).

It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

0.8 mL
0.4 mL
Submitting the minimum volume does not allow for repeat testing



Gold serum separator (SST) tube


Spin and separate


Ambient (preferred) - 5 days

Refrigerated - 14 days

Frozen - 14 days

LabCorp Burlington (081700): R-NX
Mo - Fr
1 - 2 days

Electrochemiluminescence Immunoassay (ECLIA)



Range (pmol/L)


Not established



   0 - 39 years               

0.0 - 61.2

   40 - 49 years           

0.0 - 63.6

   50 - 59 years               

0.0 - 105.2

   60 - 69 years                

0.0 - 96.5

   > 69 years                     

0.0 - 96.9

Biotin supplement interference - see patient preparation
Result 55180-4