Leflunomide

Alphabetical Test listing

Leflunomide-994

  
Leflunomide
  
994
  
LAB994
  
MSO
  
A77/1726
Arava
Teriflunomide
  

Leflunomide (Arava®) is a pyrimidine synthesis inhibitor used in the treatment of active rheumatoid arthritis. The drug is available in oral doses containing 10, 20, or 100 mg of active drug. Arava® is an isoxazole immunodulatory agent which inhibits dihydroorotate dehydrogenase (an enzyme involved in de novo pyrimidine synthesis) and has antiproliferative activity. Following oral administration, leflunomide is metabolized to an active metabolite, A77-1726 (teriflunomide), which is responsible for essentially all of its activity in vivo. Peak levels of this metabolite occurred 6 to 12 hours after dosing, with a long half-life (about two weeks).

  
Serum
  
  
1.0 mL
  
0.5 mL
Submitting the minimum volume does not allow for repeat testing
  
  1. Spin and separate within 45 minutes of specimen collection
  2. Freeze
  

Frozen (strict) - 6 months

Refrigerated - NO

Ambient - NO

  
  • Non-frozen sample
  • Gel-barrier tube
  
LabCorp Burlington (070021): R-NX
  
Tu, Th
  
2 - 7 days
  

Liquid Chromatography Tandem Mass Spectrometry (LCMSMS)

  

An interpretive report will be provided

  
80375
  
Yes
  
  
Result 38901-5
  
05/24/2019
  
05/24/2019