Antichromatin antibodies

Alphabetical Test listing

Antichromatin antibodies-994

Test name:

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

Antibodies to LE cell

Useful for:

Help to diagnose drug-induced lupus (DIL) and systemic lupus erythematosus (SLE).

Antibodies to both chromatin and histones have been found in patients with procainamide-induced lupus; however, patients with lupus induced by drugs such as quinidine, penicillamine, methyldopa, and acebutolol have antibodies to chromatin but not antihistone. Antichromatin antibodies are found in 50% to 90% of SLE patients and have been linked with proteinuria in SLE patients.

Specimen type:

Serum

Collection container:

Gold serum separator (SST) tube

Volume:

1.0 mL

Minimum volume:

0.5 mL
Submission of the minimum volume does not allow for repeat testing

Collection instructions:

Immediatley following collection, mix sample by gently inverting 5 times

Processing instructions:

Allow sample to clot for a minimum of 30 minutes
Spin within two (2) hours of sample collection

Transport container:

Gold serum separator (SST) tube

Alternate collection container:

Red serum vial/tube, 5 mL

Alternate processing instructions:

Allow sample to clot
Spin within two (2) hours of sample collection
Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum

Alternate transport container:

Transfer vial/tube with cap - 12mL (LabCorp)

Transport and stability:

Ambient (preferred) - 14 days

Refrigerated - 14 days

Frozen - 14 days

Freeze/thaw cycles - stable x3

Reason for rejection:

Hemolysis

Performing lab:

LabCorp Burlington (012580): R-NX

Days set up:

Mo - Sa

TAT:

4 days

Method:

Multiplex flow immunoassay

Reference ranges:

0.0 - 0.9 AI

CPT codes:

86235

LOINC code:

Result 51775-5

Date created:

06/03/2019

Revised date:

03/17/2022

Review date:

12/07/2023