Cytochrome P450 3A4/3A5 genotyping

Alphabetical Test listing

Cytochrome P450 3A4/3A5 genotyping-994

  
Cytochrome P450 3A4/3A5 genotyping
  
994
  
LAB994
  
MSO
  
CYP3A4
CYP3A5
  

This test provides genotypes for CYP3A4 and CYP3A5 and determines estimated metabolic activity. CYP3A4 and CYP3A5 cytochrome P450 enzymes are involved in the hepatic metabolism of up to 50% of all clinically used drugs. There is wide variation in enzyme activity, particularly for CYP3A4 (10-100 fold), due to both genetic and nongenetic factors. The cause of much of the variation is not yet understood.

  
EDTA whole blood
  
  
7 mL
  
3 mL
  

Immediately following sample collection, invert the tube several times to mix

  

Lavender (EDTA), 10mL

  
ACD whole blood
  

Yellow ACD (A or B)

 

  

Yellow ACD (A or B)

  

Ambient (preferred) - 14 days

Refrigerated - 14 days

  
  • Frozen specimen
  •  Hemolysis
  • Quantity not sufficient for analysis (QNS)
  • Improper container
  
LabCorp Burlington (504155): R-NX
  
Tu
  
7 - 10 days
  

Multiplex polymerase chain reaction (PCR) and primer extension

  

Normal

  
81230
81231
  
Yes
  
  
Result:
3A4 Genotype: 81139-8
3A5 Genotype: 81140-6
  
07/31/2019
  
02/03/2021
  
06/03/2020