Synaptophysin by IHC

Alphabetical Test listing

Synaptophysin by IHC-12376 - Technical only, 12379 - Technical & interpretation

Synaptophysin by IHC
12376 - Technical only, 12379 - Technical & interpretation
  • All IHC stains will include a positive control tissue
  • Use in a panel for neuroendocrine tumors
  • Other neuroendocrine markers include chromogranin, Leu-7 (and NSE)
  • Synaptophysin is more specific than NSE and has not been detected in non-neuroendocrine cells
  • Synaptophysin is usually used in combination with chromogranin to increase the sensitivity

Submit a formalin-fixed, paraffin embedded tissue block


Formalin-fixed, paraffin embedded (FFPE) tissue block


FFPE tissue section mounted on a charged, unstained slide


Ambient (preferred)

  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
AHL - Immunohistochemistry
Mo - Fr
1 - 2 days

Immunohistochemical staining and microscopic examination


If requested, an interpretive report will be provided



  • Synaptophysin is a glycoprotein present in pre-synaptic vesicles of neurons, and in neurosecretory granules of neuroendocrine cells

Staining pattern

  • Diffuse granular cytoplasmic-based staining in neuroendocrine cells
  • Punctate cytoplasmic-based staining in neurons

88342 - 1st stain
88341 - each additional stain