Synaptophysin by IHC

Alphabetical Test listing

Synaptophysin by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
Synaptophysin by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
  • All IHC stains will include a positive control tissue
  
  • Use in a panel for neuroendocrine tumors
  • Other neuroendocrine markers include chromogranin, Leu-7 (and NSE)
  • Synaptophysin is more specific than NSE and has not been detected in non-neuroendocrine cells
  • Synaptophysin is usually used in combination with chromogranin to increase the sensitivity
  
Tissue
  

Submit a formalin-fixed, paraffin embedded tissue block

  

Formalin-fixed, paraffin embedded (FFPE) tissue block

  

FFPE tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • Synaptophysin is a glycoprotein present in pre-synaptic vesicles of neurons, and in neurosecretory granules of neuroendocrine cells

Staining pattern

  • Diffuse granular cytoplasmic-based staining in neuroendocrine cells
  • Punctate cytoplasmic-based staining in neurons

  
88342 - 1st stain
88341 - each additional stain
  
09/13/2017
  
10/17/2018
  
10/02/2020