B-Cell Lymphoblastic Leukemia (B-ALL) monitoring, minimal residual disease (MRD) detection

Alphabetical Test listing

B-Cell Lymphoblastic Leukemia (B-ALL) monitoring, minimal residual disease (MRD) detection-994

  
B-Cell Lymphoblastic Leukemia (B-ALL) monitoring, minimal residual disease (MRD) detection
  
994
  
LAB994
  
MSO
  
Acute minimal residual disease
ALL-MRD
B-ALL MRD
B-cell ALL MRD
  

Aids in monitoring a previously confirmed diagnosis of B-cell lymphoblastic leukemia

  
Bone marrow
  

Yellow ACD (A or B)

 

  
6.0 mL
  
2.0 mL
  
  • Submission of bilateral specimens is not required
  • Label specimen appropriately (bone marrow)
  

Include 5 to 10 unstained bone marrow aspirate smears, if possible.

  

Yellow ACD (A or B)

  
Whole blood; ACD-A, ACD-B, EDTA or Sodium heparin
  

Bone marrow

Dk green Sodium heparin (Na hep), no gel

Lavender (EDTA), 4mL

 

Whole blood:

Yellow ACD (A or B)

 

 

Lavender (EDTA), 4mL

Dk green Sodium heparin (Na hep), no gel

  
6 mL (minimum 2.0 mL)
  

Immediately following collection, mix sample thoroughly by gentle inverting 8 - 10 times, to prevent clotting

  
  1. Send original collection tube, do not aliquot
  2. Label as blood
  3. If possible, include 5 to 10 unstained blood smears
  

Dk green Sodium heparin (Na hep), no gel

Lavender (EDTA), 4mL

  

Copy of flow cytometry report

  

Ambient - 72 hours

Specimen must be received at MCL within 72 hours

  
Mayo Clinic Laboratories (BALLM): R-NX
  
Mo - Fr
  
1 - 4 days
  

Immunophenotyping

  

This test will be processed as a laboratory consultation. An interpretation of the immunophenotypic findings and correlation with the morphologic features will be provided by a hematopathologist for every case.

  

This test is only appropriate for patients who have a previous confirmed diagnosis of B-cell lymphoblastic leukemia.

Treatment with antibodies to CD19 may interfere with the ability to detect minimal residual disease (MRD).

  
88184 - Flow cytometry
first cell surface, cytoplasmic or nuclear marker
88185 x 9 - Flow cytometry
additional cell surface, cytoplasmic or nuclear marker (each)
88188 - Flow Cytometry Interpretation, 9 to 15 Markers (if appropriate)
  
07/02/2019
  
03/09/2023
  
03/08/2023