Apolipoprotein A-1
Apolipoprotein A-1-13353
Alpha Apolipoprotein
Apo A-1
Patient should fast 12 - 14 hours prior to specimen collection
- Allow sample to clot
- Spin within two (2) hours of sample collection
- Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum
Heparin plasma
Immediatley following collection, mix sample by inverting 8 - 10 times
Gold:
- Allow sample to clot for a minimum of 30 minutes
- Spin within two (2) hours of sample collection
Lavender/Dk green:
- Spin within two (2) hours of sample collection
- Transfer plasma to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as the appropriate plasma type
Ambient (preferred) - 14 days
Refrigerated - 14 days
Frozen - 14 days
Freeze/thaw cycles - stable x 3
- Specimen from nonfasting patient
Immunologic
An interpretive report will be provided
Apo A-1 comprises 60% to 70% of the protein content of HDL. Apo A-1 serves as an activator of LCAT which is involved in the transport of cholesterol from peripheral tissues to the liver where it is degraded. Decreased serum HDL cholesterol levels have been reported to correlate with increased risk of coronary artery disease (CAD); however, Apo A-1 has been suggested as a better discrimination of CAD than HDL. Apo A-1 levels also correlate with survival rates or risk factors for patients with myocardial infarction and peripheral vascular disease. Measurement of Apo A-1 may also aid in the diagnosis of Tangier disease (absence of alpha-lipoprotein).