CLL progressive panel by FISH

Alphabetical Test listing

CLL progressive panel by FISH-Order the individual components; 4280H (blood) or 4280G (bone marrow)

  
CLL progressive panel by FISH
  
Order the individual components; 4280H (blood) or 4280G (bone marrow)
  
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES
LAB4280G - CYTOGENETIC BONE MARROW STUDIES
  
ATM
TP53
  
ATM deletion
CLL
Chronic Lymphocytic Leukemia
SLL
Small Lymphocytic lymphoma
17p13.1 deletion
TP53 deletion
11p22 deletion
  
  • ATM
  • TP53
  

The CLL Progressive Panel is useful for detecting the poor/adverse cytogenetics FISH abnormalities for follow-up CLL/SLL cases.

  
Sodium heparin (Na hep) whole blood
  
  
5 mL
  
2.0 mL
  

Only one specimen tube is required to perform all ordered cytogenetics testing.

The more testing ordered, the closer to the optimal volume requirements is preferred.

  

Dk green Sodium heparin (Na hep), no gel

  
Bone marrow
EDTA whole blood (a chromosome analysis study is not recommended for this specimen type)
  
  
Bone marrow: 10 mL (minimum 5 mL)
  

Bone marrow

Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube

  

- or -

Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel

  

Bone marrow:

Sterile vial/tube

Dk green Sodium heparin (Na hep), no gel

 

EDTA whole blood:

Lavender (EDTA), 4mL

  
  • AHL Cytogenetics oncology request
  

Ambient

  
Pellets - 2 years
  
  • Improper label (unlabeled or mislabeled)
  • Wrong container (anticoagulant or solution)
  • Improper blood/anticoagulant ratio
  • Delay in transport
  • Improper storage
  • Leaking container
  
AHL - Cytogenetics: X
  
As needed
  
5 - 7 days
  

Fluorescence in situ hybridization (FISH)

  

Normal or Abnormal with interpretation.

Deletion of ATM or TP53 are classified as unfavorable cytogenetics prognostic indicators in CLL/SLL.

  
88271 x 2
88275 x 1
  
Yes
  
03/18/2021
  
04/06/2021