Since the first report of a hereditary deficiency of AT III and its consequences in 1965, AT III has been considered an important parameter in spontaneous thromboembolic disorders. The hereditary deficiency, either quantitative or qualitative, is less common than the acquired deficiency. An acquired AT III deficiency has been described in DIC, septic shock, nephrotic syndrome, liver disease and in L-asparaginase treatments.
Do not over or under fill tube as the ratio of anticoagulant to whole blood is critical
If the patient has a hematocrit >55, a specially prepared Lt blue Sodium citrate (NaCit) tube must be used in place of the standard Lt blue Sodium citrate (NaCit) tube.
Mix by gentle inversion 3 - 4 times
Process Platelet Poor Plasma (P.P.P)
Frozen (strict) - 2 weeks
Refrigerated - NO
|Age||Range in %|
|0 - 5 days||40-95|
|6 - 30 days||48-108|
|1 – 6 mo||70-125|